Endocrine Abstracts

Introduction: Monotherapy failure in diabetes mellitus type 2 occurs early in the course of disease. Evaluation of the primary pathogenetic mechanism is of primary importance in choosing the optimal combination therapy.Objectives: To investigate influence of meal stimulated C-peptide levels and HOMA B, as markers of residual insulin secretion on the efficasy of adding metformin to sulphonylurea therapy in subjects with metabolic syndrome, type 2 diabetes...

Metabolic syndrome (MetS) is known to be associated with low levels of vitamin D. The association of vitamin D in postmenopausal women with MetS and osteoporosis has not been investigated. The aim of our investigation was to assess presence of MetS in postmenopausal women treated for osteoporosis.Metods: Fifty-nive women treated with weekly alendronate, vitamin D (Fosavance 5600, MSD) and calcium for 1 year were evaluated. The following parameters were a...

Introduction: Prediabetes carries a risk of diabetes and cardiovascular disease (CVD). Assessment of CVD risk in prediabetes is not as routine, as is assessment of diabetes risk. However, it is not less important. This can be done through conventional SCORE charts and through coronary artery calcium (CAC) score. CAC is examined through multislice CT. Calcifications indicate late-stage subclinical coronary atherosclerosis. The AIM of our study was to assess traditional CVD risk...

Introduction: Coronary artery calcium (CAC) is examined through multislice CT. Calcifications indicate late-stage subclinical coronary atherosclerosis. An association exists between CAC with coronary vascular disease (CVD), Agatston score being an independent predictor of CVD. Including CAC may improve CV risk prediction in addition to conventional risk factors. The AIM of our study was to assess CAC in subjects with prediabetes (preDM) at the beginning of the long term follow...

Introduction: Low concentration of serum 25-hydroxyvitamin D (25-OHvitD) have been associated with low bone loss and risk of falls in postmenopausal women. Moderate obesity is not a risk factor for osteoporosis.Aim: The aim of this study was to investigate how vitamin D concentration correlates with muscle strength and bone density in moderately obese postmenopausal women.Methods: We include 33 postmenopausal women, between 50 and ...

Background: Optimal testing of beta-cell dysfunction is still elusive. Oral based solid-food tests could superiorly approximate real-life stimulation by incorporating incretin activation. Increased body fat was recently associated with better preserved beta-cell secretory response, due to gluco-lipotoxicity induced adaptation.Objective: To assess C-peptide response to standardised test meal (STM) and its dependency on subject characteristics in newly dia...

Background: Vascular complications are leading cause of increased morbidity and mortality of diabetic patients. Pathophysiological mechanisms included in the development and progression of diabetic complications are various and lately it has been postulated that matrix metalloproteinases MMP-2 and MMP-9, zinc-dependent endopeptidases through remodeling of extracellular matrix can contribute to the onset and progression of diabetic vascular complications. The aim of our study w...

Abdominal obesity and metabolic syndrome are known to increase in prevalence from premenopause to postmenopause in women. Both are well recognized predictors of cardiovascular disease and diabetes in women.The objective of this study was to assess the presence of obesity and metabolic syndrome during the menopausal transition in women from Serbia.Methods: Our results present a part of the National epidemiological cross-sectional st...